At the 2023 GastroPlus® User Meeting, Lecturer Takeda gave an invited lecture titled "Evaluation of Strain Differences in Four Rat Strains for the Anticoagulant Rodenticide Diphacinone Using PK/PD Analysis and PBPK Modeling."

GastroPlus® allows for the creation of dynamic pharmacokinetic models under various conditions by setting parameters for intestinal absorption and liver metabolism (Physiology-Based Pharmacokinetics, PBPK analysis). In his lecture, Takeda discussed how this was applied not just to laboratory rats but also to wild black rats and even rodenticide-resistant wild black rats, presenting a case where PBPK analysis of rodenticides was conducted in non-model animals.

We published a research article related to the lecture.

Takeda K. et al., Sensitivity assessment of diphacinone by pharmacokinetic analysis in invasive black rats in the Bonin (Ogasawara) Archipelago, Japan, Pesticide Biochemistry and Physiology, V199, February 2024, 105767

https://doi.org/10.1016/j.pestbp.2023.105767