Publications

Publication

2026

• "An Ordinary Differential Equation-Based Integrated Pharmacokinetic–Pharmacodynamic Model for Predicting Anticoagulant Responses to Warfarin and Diphacinone Across Rodent and Bat Species"
  Misaki Fukamatsu, Moyu Miyamae, Ryo Kamata, Kazuki Takeda*
  The Journal of Veterinary Medical Science 88, 7, In Press (2026).

  • DOI: https://doi.org/10.1292/jvms.26-0177
• "Isomer-Dependent Pharmacokinetic Behavior and VKOR Interactions of Second-Generation Anticoagulant Rodenticides: An Integrated In Vivo–In Vitro–In Silico Investigation"
  Moyu Miyamae, Satoru Nagaoka, Teppei Hayama, Misaki Fukamatsu, Ryo Kamata, Kazuki Takeda*
  International Journal of Molecular Sciences 27, 9, 3794 (2026).

  • DOI: https://doi.org/10.3390/ijms27093794
• "Perfluorohexanesulfonic acid-induced inhibition of human palate cell proliferation through upregulation of miR-374a-5p"
  Hiroki YOSHIOKA, Hanane HORITA, Kenichi OGATA, Kazuki TAKEDA, Hyogo HORIGUCHI, Yosuke TSUKIBOSHI
  Biomedical Research 47, 1, 1 - 10 (2026).

  • DOI: https://doi.org/10.2220/biomedres.47.1

2025

• "A New Class of Vitamin K Analogues Containing the Side Chain of Retinoic Acid Have Enhanced Activity for Inducing Neuronal Differentiation"
  Yoshihisa Hirota, Taiki Sato, Rina Watanabe, Kazuki Takeda, Sho Sano, Satoshi Asano, Yuki Shibahashi, Yumi Yasuda, Yuta Takagi, Yutaro Yamashita, Wu YuXin, Mikino Arakawa, Yuri Maitani, Vannessa Lawai, Kurumi Nakagawa, Natsuko Furukawa, Atsuko Takeuchi, Chisato Tode, Maya Kamao, Akimori Wada, Zainab Ngaini, Yoshitomo Suhara
  ACS Chemical Neuroscience 16, 15, 2812–2828 (2025).

  • DOI: https://doi.org/10.1021/acschemneuro.5c00111
• "Development and Mechanistic Evaluation of a Lithocholic Acid Derivative as an Environmentally Safe Rodenticide"
  Kazuki Takeda*, Kana Okamura, Satoru Nagaoka, Chiharu Ogura, Misaki Fukamatsu, Mayumi Degawa, Hiroyuki Kagechika, Kenji Ohgane, Ryo Kamata, Aya Tanatani*
  ACS Pharmacology & Translational Science (2025).

  • DOI: https://doi.org/10.1021/acsptsci.5c00059
• "Comprehensive molecular docking on the AlphaFold-predicted protein structure proteome: identifying target protein candidates for puberulic acid"
  Teppei Hayama, Rin Sugawara, Ryo Kamata, Masakazu Sekijima, Kazuki Takeda*
  The Journal of Toxicological Sciences 50, 7, 309-324 (2025).

  • DOI: https://doi.org/10.2131/jts.50.309
• "Protective function of the voltage-gated potassium channel Kv11.3 in a mouse model of cardiac ischemia/reperfusion injury"
  Hayato Sasaki, Kazuki Otake, Kazuki Takeda, Karin Tesaki, Eiki Takahashi, Jumpei Yasuda, Shizukaze Matsuda, Ayumu Kawasaki, Masaki Watanabe, Kosuke Otani, Muneyoshi Okada, Masakazu Sekijima, Hideyuki Yamawaki, Nobuya Sasaki
  PLOS One (2025).

  • URL
  • DOI: https://doi.org/10.1371/journal.pone.0323428
• "Comprehensive Molecular Docking on the AlphaFold-Predicted Protein Structure Proteome: Identifying Target Protein Candidates for Puberulic Acid, a Suspected Lethal Nephrotoxin"
  Teppei Hayama, Rin Sugawara, Ryo Kamata, Masakazu Sekijima, Kazuki Takeda
  bioRxiv (2025).

  • DOI: https://doi.org/10.1101/2025.01.30.635827

2024

• "Assessment of the Aryl Hydrocarbon Receptor–Mediated Effects of Aromatic Sensitizers in Paper Recycling Effluent Employing Zebrafish Embryos and in Silico Docking"
  Kazuki Takeda*, Aoi Sarata, Masanori Terasaki, Akira Kubota, Keita Shimizu, Ryo Kamata*
  Environmental Toxicology and Chemistry 43, 10, 2176–2188 (2024).

  • DOI: https://doi.org/10.1002/etc.5969

  Kitasato University School of Veterinary Medicine Best Paper 2024
• "Exploring 2-methyl–substituted vitamin K3 derivatives with potent inhibitory activity against the 3CL protease of SARS-CoV-2"
  Ryohto Koharazawa, Mayu Hayakawa, Kazuki Takeda, Kotone Miyazaki, Chisato Tode, Yoshihisa Hirota, Yoshitomo Suhara
  Bioorganic & Medicinal Chemistry Letters 100, 129642 (2024).

  • DOI: https://doi.org/10.1016/j.bmcl.2024.129642
• "Sensitivity assessment of diphacinone by pharmacokinetic analysis in invasive black rats in the Bonin (Ogasawara) Archipelago, Japan"
  Kazuki Takeda*, Keita Shimizu, Miyu Sato, Masafumi Katayama, Shouta M.M. Nakayama, Kotaro Tanaka, Yoshinori Ikenaka, Takuma Hashimoto, Ryuichi Minato, Yusuke Oyamada, Kazuyuki D. Tanaka, Goro Kimura, Tsutomu Tanikawa, Keisuke Kato, Taichi Kusakabe, Mayumi Ishizuka, Ryo Kamata
  Pesticide Biochemistry and Physiology 199, 105767 (2024).

  • DOI: https://doi.org/10.1016/j.pestbp.2023.105767
• "Toxicity Assessment of Mixed Exposure of Nine Perfluoroalkyl Substances at Concentrations Relevant to Daily Intake"
  Kazuki Takeda*, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Makoto Sugiyama, Saeka Eto, Kio Suzuki, Ryo Kamata
  Toxics 12, 1, 52 (2024).

  • DOI: https://doi.org/10.3390/toxics12010052

  Editor’s Choice

2023

• "Subchronic Toxicity Assessment of Perfluoroalkyl Substances by Mixed Exposure of Nine Substances at Daily Intake Relevant Concentration"
  Kazuki Takeda, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Makoto Sugiyama, Kio Suzuki, Saeka Eto, Ryo Kamata
  BioRxiv (2023).

  • URL
  • DOI: 10.1101/2023.05.17.541082
• "Evaluation of anticoagulant rodenticide sensitivity by examining in vivo and in vitro responses in avian species, focusing on raptors"
  Kraisiri Khidkhan, Fuyu Yasuhira, Aksorn Saengtienchai, Chaiyan Kasorndorkbua, Ratiwan Sitdhibutr, Kohei Ogasawara, Hikaru Adachi, Yukiko Watanabe, Keisuke Saito, Hidefumi Sakai, Kazuo Horikoshi, Hajime Suzuki, Yusuke K. Kawai, Kazuki Takeda, Yared B. Yohannes, Yoshinori Ikenaka, Barnett A. Rattner, Mayumi Ishizuka, Shouta M.M. Nakayama
  Environmental Pollution 341, 122837 (2023).

  • DOI: https://doi.org/10.1016/j.envpol.2023.122837

2022

• "Observation of hapten-induced sensitization responses for the development of a mouse skin sensitization test, including the elicitation phase"
  Ryo Kamata*, Yukiko Okawa, Yuto Hamaguchi, Soma Tabata, Masanori Terasaki, & Kazuki Takeda
  Scientific Reports 12, 19898 (2022).

  • DOI: 10.1038/s41598-022-24547-1
• "Toxicokinetic analysis of the anticoagulant rodenticides warfarin & diphacinone in Egyptian fruit bats (Rousettus aegyptiacus) as a comparative sensitivity assessment for Bonin fruit bats (Pteropus pselaphon)"
  Kazuki Takeda, Kosuke Manago, Ayuko Morita, Yusuke K. Kawai, Nobuaki Yasuo, Masakazu Sekijima, Yoshinori Ikenaka, Takuma Hashimoto, Ryuichi Minato, Yusuke Oyamada, Kazuo Horikoshi, Hajime Suzuki, Mayumi Ishizuka, Shouta M.M. Nakayama*
  Ecotoxicology and Environmental Safety 243, 15, 113971 (2022).

  • DOI: 10.1016/j.ecoenv.2022.113971
• "ESTIMATING SUSCEPTIBILITY OF RODENTICIDE BY MOLECULAR DYNAMICS & MACHINE LEARNING USING 3D STRUCTURES OF VITAMIN K EPOXIDE REDUCTASE"
  Kazuki Takeda, Nobuaki Yasuo, Kanami Watanabe, Ryo Sato, Ryo Kamata, and Masakazu Sekijima
  The Pure and Applied Chemistry International Conference 2022 Proceedings (2022).

  ISBN: 978-616-338-176-7
• "Evaluation of human thyroid receptor-agonist activity in 796 chemical compounds using a yeast two-hybrid assay with Saccharomyces cerevisiae Y190"
  Ryo OMAGARI, Mayuko YAGISHITA, Miho YAMASAKI, Ryo KAMATA, Masanori TERASAKI, Fujio SHIRAISHI, Takuya KUBO, and Daisuke NAKAJIMA
  Environmental Monitoring and Contaminants Research 2, 54-59 (2022).

  • DOI: 10.5985/emcr.20210016
• "Evaluation of human thyroid hormone receptor-antagonist activity in 691 chemical compounds using a yeast two-hybrid assay with Saccharomyces cerevisiae Y190"
  Ryo Omagari, Mayuko Yagishita, Fujio Shiraishi, Ryo Kamata, Masanori Terasaki, Takuya Kubo, Daisuke Nakajima
  Data in Brief 42, 108303 (2022).

  • DOI: 10.1016/j.dib.2022.108303
• "Development of a sandwich enzyme-linked immunosorbent assay (ELISA) to quantify γ-glutamyl-carboxylated clotting factor IX and assess redox susceptibility of anticoagulant chemicals"
  Ryo SATO & Kanami WATANABE, Ryo KAMATA, and Kazuki TAKEDA*
  Journal of Veterinary Medical Science 84, 6 (2022).

  • DOI: 10.1292/jvms.22-0079

2021

• "The effects of fipronil on emotional and cognitive behaviors in mammals"
  Tomohiro Suzuki, Anri Hirai, Kraisiri Khidkhan, Collins Nimako, Takahiro Ichise, Kazuki Takeda, Hazuki Mizukawa, Shouta M.M. Nakayama, Kei Nomiyama, Nobuhiko Hoshi, Mizuki Maeda, Tetsushi Hirano, Kazuyoshi Sasaoka, Noboru Sasaki, Mitsuyoshi Takiguchi, Mayumi Ishizuka, Yoshinori Ikenaka
  Pesticide Biochemistry and Physiology 175, 104847 (2021).

  • DOI: 10.1016/j.pestbp.2021.104847
• "Sensitivity of turtles to anticoagulant rodenticides: risk assessment for green sea turtles (Chelonia mydas) in the Ogasawara Islands and comparison of warfarin sensitivity among turtle species"
  Yoshiya Yamamura, Kazuki Takeda, Yusuke K. Kawai, Yoshinori Ikenaka, Chiyo Kitayama, Satomi Kondo, Chiho Kezuka, Mari Taniguchi, Mayumi Ishizuka, Shouta M.M. Nakayama
  Aquatic Toxicology 233, 105792 (2021).

  • DOI: 10.1016/j.aquatox.2021.105792
• "The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus)"
  Kazuki Takeda , Yoshinori Ikenaka , Denis Fourches , Kazuyuki D. Tanaka , Shouta M.M. Nakayama , Dhoha Triki , Xinhao Li , Manabu Igarashi , Tsutomu Tanikawa , Mayumi Ishizuka
  Pesticide Biochemistry and Physiology 173, 104774 (2021).

  • DOI: 10.1016/j.pestbp.2021.104774

2020

• "Avian eggshell thinning caused by transovarian exposure to o,p'-DDT: changes in histology and calcium-binding protein production in the oviduct uterus"
  Ryo Kamata, Fujio Shiraishi and Kazuichi Nakamura
  The Journal of Toxicological Sciences 45, 3, 311-316 (2020).

  • DOI: 10.2131/jts.45.131

2019

• "A comparative study of nickel nanoparticle and ionic nickel toxicities in zebrafish: histopathological changes and oxidative stress"
  Shohei Yokota, Kazuichi Nakamura, Ryo Kamata
  The Journal of Toxicological Sciences 44, 11, 737-751 (2019).

  • DOI: 10.2131/jts.44.737
• "Measurement of the agonistic activities of monohydroxylated polychlorinated biphenyls at the retinoid X and retinoic acid receptors using recombinant yeast cells"
  Ryo Kamata, Daisuke Nakajima, Fujio Shiraishi
  Toxicology in vitro 57, 9, 9-17 (2019).

  • DOI: 10.1016/j.tiv.2019.01.022

2018

• "Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay"
  Fujio Shiraishi, Ryo Kamata, Masanori Terasaki, Hidetaka Takigami, Yoshitaka Imaizumi, Mayuko Yagishita, Daisuke Nakajima
  Data in brief 21, 2543-2546 (2018).

  • DOI: 10.1016/j.dib.2018.11.071
• "Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay"
  Ryo Kamata, Daisuke Nakajima, Fujio Shiraishi
  Toxicology in vitro 46, 335-349 (2018).

  • DOI: 10.1016/j.tiv.2017.09.014