School of Veterinary Medicine, Kitasato University
Laboratory of Toxicology
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School of Veterinary Medicine, Kitasato University
Laboratory of Toxicology
日本語
|
English
HOME
Research
Professors
Recruitment
Publications
Publication
Domestic conference
International conference
Awards
Books
Japanese Proceedings
Blog
Link
Access / Contact
Publications
Publications
Publication
Publication
2025
"Comprehensive Molecular Docking on the AlphaFold-Predicted Protein Structure Proteome: Identifying Target Protein Candidates for Puberulic Acid, a Suspected Lethal Nephrotoxin"
Teppei Hayama, Rin Sugawara, Ryo Kamata, Masakazu Sekijima, Kazuki Takeda
bioRxiv
(2025)
.
DOI: https://doi.org/10.1101/2025.01.30.635827
2024
"Assessment of the Aryl Hydrocarbon Receptor–Mediated Effects of Aromatic Sensitizers in Paper Recycling Effluent Employing Zebrafish Embryos and in Silico Docking"
Kazuki Takeda, Aoi Sarata, Masanori Terasaki, Akira Kubota, Keita Shimizu, Ryo Kamata
Environmental Toxicology and Chemistry
43
,
10
,
2176–2188
(2024)
.
DOI: https://doi.org/10.1002/etc.5969
"Exploring 2-methyl–substituted vitamin K3 derivatives with potent inhibitory activity against the 3CL protease of SARS-CoV-2"
Ryohto Koharazawa, Mayu Hayakawa, Kazuki Takeda, Kotone Miyazaki, Chisato Tode, Yoshihisa Hirota, Yoshitomo Suhara
Bioorganic & Medicinal Chemistry Letters
100
,
129642
(2024)
.
DOI: https://doi.org/10.1016/j.bmcl.2024.129642
"Sensitivity assessment of diphacinone by pharmacokinetic analysis in invasive black rats in the Bonin (Ogasawara) Archipelago, Japan"
Kazuki Takeda, Keita Shimizu, Miyu Sato, Masafumi Katayama, Shouta M.M. Nakayama, Kotaro Tanaka, Yoshinori Ikenaka, Takuma Hashimoto, Ryuichi Minato, Yusuke Oyamada, Kazuyuki D. Tanaka, Goro Kimura, Tsutomu Tanikawa, Keisuke Kato, Taichi Kusakabe, Mayumi Ishizuka, Ryo Kamata
Pesticide Biochemistry and Physiology
199
,
105767
(2024)
.
DOI: https://doi.org/10.1016/j.pestbp.2023.105767
"Toxicity Assessment of Mixed Exposure of Nine Perfluoroalkyl Substances at Concentrations Relevant to Daily Intake"
Kazuki Takeda, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Makoto Sugiyama, Saeka Eto, Kio Suzuki, Ryo Kamata
Toxics
12
,
1
,
52
(2024)
.
DOI: https://doi.org/10.3390/toxics12010052
Editor’s Choice
2023
"Subchronic Toxicity Assessment of Perfluoroalkyl Substances by Mixed Exposure of Nine Substances at Daily Intake Relevant Concentration"
Kazuki Takeda, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Makoto Sugiyama, Kio Suzuki, Saeka Eto, Ryo Kamata
BioRxiv
(2023)
.
URL
DOI: 10.1101/2023.05.17.541082
"Evaluation of anticoagulant rodenticide sensitivity by examining in vivo and in vitro responses in avian species, focusing on raptors"
Kraisiri Khidkhan, Fuyu Yasuhira, Aksorn Saengtienchai, Chaiyan Kasorndorkbua, Ratiwan Sitdhibutr, Kohei Ogasawara, Hikaru Adachi, Yukiko Watanabe, Keisuke Saito, Hidefumi Sakai, Kazuo Horikoshi, Hajime Suzuki, Yusuke K. Kawai, Kazuki Takeda, Yared B. Yohannes, Yoshinori Ikenaka, Barnett A. Rattner, Mayumi Ishizuka, Shouta M.M. Nakayama
Environmental Pollution
341
,
122837
(2023)
.
DOI: https://doi.org/10.1016/j.envpol.2023.122837
2022
"Observation of hapten-induced sensitization responses for the development of a mouse skin sensitization test, including the elicitation phase"
Ryo Kamata, Yukiko Okawa, Yuto Hamaguchi, Soma Tabata, Masanori Terasaki, & Kazuki Takeda
Scientific Reports
12
,
19898
(2022)
.
DOI: 10.1038/s41598-022-24547-1
"Toxicokinetic analysis of the anticoagulant rodenticides warfarin & diphacinone in Egyptian fruit bats (Rousettus aegyptiacus) as a comparative sensitivity assessment for Bonin fruit bats (Pteropus pselaphon)"
Kazuki Takeda, Kosuke Manago, Ayuko Morita, Yusuke K. Kawai, Nobuaki Yasuo, Masakazu Sekijima, Yoshinori Ikenaka, Takuma Hashimoto, Ryuichi Minato, Yusuke Oyamada, Kazuo Horikoshi, Hajime Suzuki, Mayumi Ishizuka, Shouta M.M. Nakayama
Ecotoxicology and Environmental Safety
243
,
15
,
113971
(2022)
.
DOI: 10.1016/j.ecoenv.2022.113971
"ESTIMATING SUSCEPTIBILITY OF RODENTICIDE BY MOLECULAR DYNAMICS & MACHINE LEARNING USING 3D STRUCTURES OF VITAMIN K EPOXIDE REDUCTASE"
Kazuki Takeda, Nobuaki Yasuo, Kanami Watanabe, Ryo Sato, Ryo Kamata, and Masakazu Sekijima
The Pure and Applied Chemistry International Conference 2022 Proceedings
(2022)
.
ISBN: 978-616-338-176-7
"Evaluation of human thyroid receptor-agonist activity in 796 chemical compounds using a yeast two-hybrid assay with Saccharomyces cerevisiae Y190"
Ryo OMAGARI, Mayuko YAGISHITA, Miho YAMASAKI, Ryo KAMATA, Masanori TERASAKI, Fujio SHIRAISHI, Takuya KUBO, and Daisuke NAKAJIMA
Environmental Monitoring and Contaminants Research
2
,
54-59
(2022)
.
DOI: 10.5985/emcr.20210016
"Evaluation of human thyroid hormone receptor-antagonist activity in 691 chemical compounds using a yeast two-hybrid assay with Saccharomyces cerevisiae Y190"
Ryo Omagari, Mayuko Yagishita, Fujio Shiraishi, Ryo Kamata, Masanori Terasaki, Takuya Kubo, Daisuke Nakajima
Data in Brief
42
,
108303
(2022)
.
DOI: 10.1016/j.dib.2022.108303
"Development of a sandwich enzyme-linked immunosorbent assay (ELISA) to quantify γ-glutamyl-carboxylated clotting factor IX and assess redox susceptibility of anticoagulant chemicals"
Ryo SATO & Kanami WATANABE, Ryo KAMATA, and Kazuki TAKEDA
Journal of Veterinary Medical Science
84
,
6
(2022)
.
DOI: 10.1292/jvms.22-0079
2021
"The effects of fipronil on emotional and cognitive behaviors in mammals"
Tomohiro Suzuki, Anri Hirai, Kraisiri Khidkhan, Collins Nimako, Takahiro Ichise, Kazuki Takeda, Hazuki Mizukawa, Shouta M.M. Nakayama, Kei Nomiyama, Nobuhiko Hoshi, Mizuki Maeda, Tetsushi Hirano, Kazuyoshi Sasaoka, Noboru Sasaki, Mitsuyoshi Takiguchi, Mayumi Ishizuka, Yoshinori Ikenaka
Pesticide Biochemistry and Physiology
175
,
104847
(2021)
.
DOI: 10.1016/j.pestbp.2021.104847
"Sensitivity of turtles to anticoagulant rodenticides: risk assessment for green sea turtles (Chelonia mydas) in the Ogasawara Islands and comparison of warfarin sensitivity among turtle species"
Yoshiya Yamamura, Kazuki Takeda, Yusuke K. Kawai, Yoshinori Ikenaka, Chiyo Kitayama, Satomi Kondo, Chiho Kezuka, Mari Taniguchi, Mayumi Ishizuka, Shouta M.M. Nakayama
Aquatic Toxicology
233
,
105792
(2021)
.
DOI: 10.1016/j.aquatox.2021.105792
"The VKORC1 ER-luminal loop mutation (Leu76Pro) leads to a significant resistance to warfarin in black rats (Rattus rattus)"
Kazuki Takeda , Yoshinori Ikenaka , Denis Fourches , Kazuyuki D. Tanaka , Shouta M.M. Nakayama , Dhoha Triki , Xinhao Li , Manabu Igarashi , Tsutomu Tanikawa , Mayumi Ishizuka
Pesticide Biochemistry and Physiology
173
,
104774
(2021)
.
DOI: 10.1016/j.pestbp.2021.104774
2020
"Avian eggshell thinning caused by transovarian exposure to o,p'-DDT: changes in histology and calcium-binding protein production in the oviduct uterus"
Ryo Kamata, Fujio Shiraishi and Kazuichi Nakamura
The Journal of Toxicological Sciences
45
,
3
,
311-316
(2020)
.
DOI: 10.2131/jts.45.131
2019
"A comparative study of nickel nanoparticle and ionic nickel toxicities in zebrafish: histopathological changes and oxidative stress"
Shohei Yokota, Kazuichi Nakamura, Ryo Kamata
The Journal of Toxicological Sciences
44
,
11
,
737-751
(2019)
.
DOI: 10.2131/jts.44.737
"Measurement of the agonistic activities of monohydroxylated polychlorinated biphenyls at the retinoid X and retinoic acid receptors using recombinant yeast cells"
Ryo Kamata, Daisuke Nakajima, Fujio Shiraishi
Toxicology in vitro
57
,
9
,
9-17
(2019)
.
DOI: 10.1016/j.tiv.2019.01.022
2018
"Screening data for the endocrine disrupting activities of 583 chemicals using the yeast two-hybrid assay"
Fujio Shiraishi, Ryo Kamata, Masanori Terasaki, Hidetaka Takigami, Yoshitaka Imaizumi, Mayuko Yagishita, Daisuke Nakajima
Data in brief
21
,
2543-2546
(2018)
.
DOI: 10.1016/j.dib.2018.11.071
"Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay"
Ryo Kamata, Daisuke Nakajima, Fujio Shiraishi
Toxicology in vitro
46
,
335-349
(2018)
.
DOI: 10.1016/j.tiv.2017.09.014
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