Publications

Domestic conference

2025

• "A Novel Species-Sensitive Animal Species Difference Assessment Method for Anti-Haemagglutinating Rodenticides by Machine Learning of Target Molecular Structure Modeling"
  Moyu Miyamae;Sanae Yamamoto;Ryo Kamata;Kazuki Takeda
  7th Spring Meeting of the Japanese Society of Veterinary Pharmacology and Toxicology (2025).
• "Structural characterization of the human olfactory receptor superfamily"
  Keita Yamauchi, Koki Takaguchi, Teppei Hayama, Rin Sugawara, Ryo Kamata, Akifumi Eguchi, Kazuki Takeda
  7th Spring Meeting of the Japanese Society of Veterinary Pharmacology and Toxicology (2025).
• "''Structural Tokicology" from Towada Campus, Aomori, Japan"
  Kazuki Takeda
  1st Meeting of Researchers of Kitasato Institute (2025).

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  優秀発表賞受賞
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  Kazuki Takeda
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  指名シンポジウム

2024

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• "Trends in Vitamins and Rodenticides Based on Structural Biology"
  Kazuki Takeda
  2nd Innovation Meeting Connecting to the Next Generation of Vitaminology (2024).

  Invited
• "Molecular Simulation in Covalent Chemical Toxicity Assessment"
  Kazuki Takeda
  2nd Symposium of Additive Chemical Science Devision of The Japanese Society of Toxicology (2024).

  Invited
• "Evaluation of Vitamin K Derivatives Directed at Inhibition of Enzymes Involved in SARS-CoV-2 Proliferation"
  Mayu Hayakawa, Daiki Homma, Ryoto Obarasawa, Kazuki Takeda, Yoshitomo Suhara, Yoshihisa Hirota]
  The 144th Annual Meeting of the Pharmaceutical Society of Japan (2024).
• "In silico Binding-Proteomics Evaluation Pipeline Using AlphaFold2 Whole Structural Proteome"
  Teppei Hayama, Rin Sugawara, Ryo Kamata, Kazuki Takeda
  The 167th Annual Meeting of The Society of Japanese Veterinary Medical Sciences (2024).
• "Predicting the Pharmacokinetics of Anticoagulant Rodenticides in Wildlife Using Partial Differential Equation Modeling"
  Misaki Fukamatsu, Masafumi Katayama, Shouta M.M. Nakayama, Moyu Miyamae, Ryo Kamata, Kazuki Takeda
  The 167th Annual Meeting of The Society of Japanese Veterinary Medical Sciences (2024).

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  Wildlife Science Section Excellent Presentation Award
• "Assessment of Testicular Toxicity of Mixed Exposure of Nine Perfluoroalkyl Substances (PFASs) at Concentrations Relevant to Daily Intake"
  Wakana Yoshimura, Taki Saito, Sakura Sasaki, Makoto Sugiyama, Ryo Kamata, Kazuki Takeda
  167th Annual Meeting of the Japanese Society of Veterinary Science (2024).

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  Pharmacology and Toxicology Section Excellent Presentation Award
• "Toxicity Assessment Using the Structural Proteome in the Post-AlphaFold2 Era"
  Kazuki Takeda
  Digital Toxicology Conference (2024).

  Invited
• "Understanding species differences in drug susceptibility based on protein 3D structures: A case study on VKOR"
  Kazuki Takeda, Moyu Miyamae, Teppei Hayama, Sanae Yamamoto, Ryo Kamata
  The 51st Annual Meeting of Japanese Society of Toxicology (2024).
• "Pharmacokinetic and Pharmacodynamic (PK/PD) Analysis for Susceptibility Assessment of the Invasive Rat Population in Ogasawara Father Island to the Rodenticide Diphacinone"
  Kotaro Tanaka, Keita Shimizu, Miyu Sato, Masafumi Katayama, Shouta M.M. Nakayama, Yoshinori Ikenaka, Takahiro Ichise, Takuma Hashimoto, Ryuichi Minato, Yusuke Oyamada, Kazuyuki D. Tanaka, Goro Kimura, Tsutomu Tanikawa, Keisuke Kato, Taichi Kusakabe, Mayumi Ishizuka, Ryo Kamata, Kazuki Takeda
  3rd Joint Conference on Environmental Chemicals (2024).

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  SETAC Award
• "Evaluation of species differences in animal susceptibility to warfarin rodenticides based on in silico protein structure analysis"
  Moyu Miyamae, Sanae Yamamoto, Ryo Kamata, Kazuki Takeda
  3rd Joint Conference on Environmental Chemicals (2024).

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  Wellington Laboratories Award
• "Machine Learning Analysis of the Results of the Japanese Society of Toxicology Career Path Questionnaire"
  Kazuki Takeda
  The 51st Annual Meeting of Japanese Society of Toxicology (2024).

  Invited
• "Evaluation of the Aromatic Hydrocarbon Receptor (AhR) Activation Potential by Sensitizer-Related Compounds in Waste Paper Recycling Effluent"
  Jiayan Sun, Kazuki Takeda, Masanori Terasaki, Akifumi Eguchi, Akira Kubota, Aoi Sarata, Keita Shimizu, Ryo Kamata
  The 51st Annual Meeting of Japanese Society of Toxicology (2024).

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  Student Poster Presentation Award
• "Drug Discovery Chemistry and Toxicology in Age of Post-AlphaFold2"
  Kazuki Takeda
  The 25th Continuing Education Course of the Japanese Society of Toxicology (2024).

  Invited
• "Search for Molecules Responsible for Differences in Drug Efficacy between cis-trans Isomers of Warfarin Rodenticides"
  Moyu Miyamae, Satoru Nagaoka, Sanae Yamamoto, Ryo Kamata, Kazuki Takeda
  6th International Chemical Hazard Symposium (2024).

2023

• "Evaluation of sensitivity differences of anticoagulant rodenticide, diphacinone in four rodent strains by PK/PD analysis and PBPK modeling."
  Kazuki Takeda
  GastroPlus® Users Meeting 2023 (2023).

  Invited
• "Evolutionary history of UGT genes involved in xenobiotic metabolism in mammals and birds and their relationship to plants"
  Yusuke K. Kawai, Yoshinori Ikenaka, Shin-ichi Ikushiro, Miu Nishikawa, Noa Isshiki, Kazuki Takeda, Shouta M.M. Nakayama, Akira Kubota, Mayumi Ishizuka
  The 25th Annual Meeting of the Evolutionary Studies Society of Japan (2023).
• "Exploratory Research of Toxicity Assessment Using Protein Structure Prediction by AlphaFold2"
  武田一貴
  The 50th Annual Meeting of the Japanese Society of Toxicology (2023).

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  Invited Presentation; Frontier Seminar
• "Exploration of In Vivo Factors Contributing to Differences in Pharmacokinetics between cis-trans Isomers of Anti-Coagulant Rodenticides"
  Moyu Miyamae, Satoru Nagaoka, Sanae Yamamoto, Ryo Kamata, Kazuki Takeda
  The 50h Annual Meeting of the Japanese Society of Toxicology (2023).

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• "Evaluation of Rodenticide Susceptibility of the Natural Monument; Bonin Flying Fox using AlphaFold2 and Molecular Simulation"
  Kazuki Takeda, Yusuke K Kawai, Nobuaki Yasuo, Masakazu Sekijima, Kodai Manago, Yoshinori Ikenaka, Kazuo Horikoshi, Hajime Suzuki, Mayumi Ishizuka, Shouta MM Nakayama
  第2回環境化学物質3学会合同大会 (2023).

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• "Application of cultured cells obtained from green sea turtles for evaluation of toxicity test with anticoagulant rodenticides."
  Masafumi Katayama, Tomoichi Fukuda, Kazuki Takeda, Satomi Kondo, Toru Kiyono, Shouta Nakayama
  Japanese Geoscience Union Meeting 2023 (2023).

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• "Evaluation of Subchronic Toxicological Effects of Low Concentration Mixed Exposure of Nine Linear PFAS on Mice"
  Kazuki Takeda, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Ryo Kamata
  6th International Chemical Hazard Symposium (2023).

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2022

• "Highly Accurate Protein Structure Prediction Using AlphaFold2 for Toxicity Assessment ～Environmental Pollutants as an Application Case Study～"
  Kazuki Takeda
  The 5th Study Group on Toxicological Mechanisms of Pharmaceuticals (2022).

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  Nominating Symposium: off-target toxicity target exploration
• "2022 年に捕獲した小笠原諸島父島の外来クマネズミにおける殺鼠剤ダイ ファシノンの薬物動態‧薬力学（PK/PD）解析による感受性評価"
  清水 敬太, 佐藤 美侑, 片山 雅史, 中山 翔太, 池中 良徳, 一瀬貴大, 石塚 真由美, 鎌田 亮, 小山田 佑輔, 港 隆一, 橋本 琢磨, 田中 和之, 谷川 力, 武田 一貴
  第28回日本野生動物医学会大会 (2022).

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  最優秀賞受賞
• "小笠原諸島の外来クマネズミに対する抗血液凝固系殺鼠剤ダイファシノンの薬物動態・薬力学(PK/PD)解析による感受性評価"
  清水 敬太, 佐藤 美侑, 片山 雅史, 中山 翔太, 池中 良徳, 一瀬貴大, 石塚 真由美, 鎌田 亮, 小山田 佑輔, 港 隆一, 橋本 琢磨, 武田 一貴
  第165回日本獣医学会学術集会 (2022).

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  優秀発表賞（野生動物分科会）受賞
• "インク由来化学物質群のゼブラフィッシュ胚への芳香族炭化水素受容体(AhR)を介する毒性影響評価"
  更田 葵依, 武田 一貴, 清水 敬太, 寺崎 正紀, 鎌田 亮
  第165回日本獣医学会学術集会 (2022).
• "Construction of a method for predicting animal species differences in chemical sensitivity from human single nucleotide polymorphisms using molecular simulation"
  Kazuki Takeda, Nobuaki Yasuo, Masakazu Sekijima
  The 49th Annual Meeting of the Japanese Society of Toxicology (2022).

  Symposium (nominated): On the frontline of wildlife toxicity assessment by young researchers
• "Gazing at the risk of anticoagulant rodenticides (ARs) application from aquatic biota: Attempt to evaluate ARs toxicity in sea turtles"
  Yoshiya Yamamura, Chiyo Kitayama, Satomi Kondo, Kazuki Takeda, Takahiro Ichise, Yoshinori Ikenaka, Mayumi Ishizuka, Shouta M.M. Nakayama
  The 49th Annual Meeting of the Japanese Society of Toxicology (2022).

  Symposium (nominated): On the frontline of wildlife toxicity assessment by young researchers
• "Characterization of Clotting Factor IX Transcript variant 2 by cultured cells assay and Alphafold2"
  Kanami Watanabe, Ryo Sato, Ryo Kamata, and Kazuki Takeda
  The 49th Annual Meeting of the Japanese Society of Toxicology (2022).
• "Evaluation of Toxicological Effects of Low Concentration Mixed Exposure of Perfluoroalkyl Substances (PFASs) on Mice"
  Kazuki Takeda, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Ryo Kamata
  Joint Conference on Environmental Chemicals (2022).
• "Evaluation of Aromatic Hydrocarbon Receptor (AhR) Agonistic Activity of Sensitizer-Related Compounds Using Zebrafish"
  更田 葵依、武田 一貴、清水 敬太、寺崎 正紀、鎌田 亮
  Joint Conference on Environmental Chemicals (2022).

  SETAC Award
• "Development of resources for assessing the effects of pollutants on green sea turtles"
  Masafumi Katayama; Tomokazu Fukuda; Manabu Onuma; Kazuki Takeda; Satomi Kondo; Shouta MM Nakayama
  Japan Geoscience Union Meeting 2022 (2022).

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• "環境汚染物質による細胞内受容体作用と生物影響の検出"
  鎌田 亮
  岩手大学ソフトパス理工学総合研究センター環境科学・工学研究グループ勉強会 (2022).
• "Functional analysis of splicing variant 2 of blood coagulation factor IX"
  Kanami Watanabe, Ryo Sato, Ryo Kamata, and Kazuki Takeda
  The 4th Spring Meeting of the Japanese Society of Comparative Pharmacology and Toxicology (2022).
• "Characterization of Clotting Factor IX Transcript variant 2"
  Kanami Watanabe, Ryo Sato, Ryo Kamata, and Kazuki Takeda
  5th International Chemical Hazard Symposium (2022).

2021

• "惹起相を有する皮膚感作性試験開発のためのマウスにおける感作性物質曝露と感作反応の検証"
  鎌田 亮, 中村 和市, 武田 一貴
  第164回日本獣医学会学術集会 (2021).
• "Estimating susceptibility of rodenticide by molecular dynamics & machine learning using 3D structure of vitamin K epoxide reductase"
  Kazuki Takeda, Nobuaki Yasuo, Kanami Watanabe, Ryo Sato, Ryo Kamata, Masakazu Sekijima
  29th Symposium on Environmental Chemistry Royal Society of Chemistry Award (2021).

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  Royal Society of Chemistry Award