Publications

2022

Publication

• "Observation of hapten-induced sensitization responses for the development of a mouse skin sensitization test, including the elicitation phase"
  Ryo Kamata, Yukiko Okawa, Yuto Hamaguchi, Soma Tabata, Masanori Terasaki, & Kazuki Takeda
  Scientific Reports 12, 19898 (2022).

  • DOI: 10.1038/s41598-022-24547-1
• "Toxicokinetic analysis of the anticoagulant rodenticides warfarin & diphacinone in Egyptian fruit bats (Rousettus aegyptiacus) as a comparative sensitivity assessment for Bonin fruit bats (Pteropus pselaphon)"
  Kazuki Takeda, Kosuke Manago, Ayuko Morita, Yusuke K. Kawai, Nobuaki Yasuo, Masakazu Sekijima, Yoshinori Ikenaka, Takuma Hashimoto, Ryuichi Minato, Yusuke Oyamada, Kazuo Horikoshi, Hajime Suzuki, Mayumi Ishizuka, Shouta M.M. Nakayama
  Ecotoxicology and Environmental Safety 243, 15, 113971 (2022).

  • DOI: 10.1016/j.ecoenv.2022.113971
• "ESTIMATING SUSCEPTIBILITY OF RODENTICIDE BY MOLECULAR DYNAMICS & MACHINE LEARNING USING 3D STRUCTURES OF VITAMIN K EPOXIDE REDUCTASE"
  Kazuki Takeda, Nobuaki Yasuo, Kanami Watanabe, Ryo Sato, Ryo Kamata, and Masakazu Sekijima
  The Pure and Applied Chemistry International Conference 2022 Proceedings (2022).

  ISBN: 978-616-338-176-7
• "Evaluation of human thyroid receptor-agonist activity in 796 chemical compounds using a yeast two-hybrid assay with Saccharomyces cerevisiae Y190"
  Ryo OMAGARI, Mayuko YAGISHITA, Miho YAMASAKI, Ryo KAMATA, Masanori TERASAKI, Fujio SHIRAISHI, Takuya KUBO, and Daisuke NAKAJIMA
  Environmental Monitoring and Contaminants Research 2, 54-59 (2022).

  • DOI: 10.5985/emcr.20210016
• "Evaluation of human thyroid hormone receptor-antagonist activity in 691 chemical compounds using a yeast two-hybrid assay with Saccharomyces cerevisiae Y190"
  Ryo Omagari, Mayuko Yagishita, Fujio Shiraishi, Ryo Kamata, Masanori Terasaki, Takuya Kubo, Daisuke Nakajima
  Data in Brief 42, 108303 (2022).

  • DOI: 10.1016/j.dib.2022.108303
• "Development of a sandwich enzyme-linked immunosorbent assay (ELISA) to quantify γ-glutamyl-carboxylated clotting factor IX and assess redox susceptibility of anticoagulant chemicals"
  Ryo SATO & Kanami WATANABE, Ryo KAMATA, and Kazuki TAKEDA
  Journal of Veterinary Medical Science 84, 6 (2022).

  • DOI: 10.1292/jvms.22-0079

Domestic conference

• "Highly Accurate Protein Structure Prediction Using AlphaFold2 for Toxicity Assessment ～Environmental Pollutants as an Application Case Study～"
  Kazuki Takeda
  The 5th Study Group on Toxicological Mechanisms of Pharmaceuticals (2022).

  • URL

  Nominating Symposium: off-target toxicity target exploration
• "2022 年に捕獲した小笠原諸島父島の外来クマネズミにおける殺鼠剤ダイ ファシノンの薬物動態‧薬力学（PK/PD）解析による感受性評価"
  清水 敬太, 佐藤 美侑, 片山 雅史, 中山 翔太, 池中 良徳, 一瀬貴大, 石塚 真由美, 鎌田 亮, 小山田 佑輔, 港 隆一, 橋本 琢磨, 田中 和之, 谷川 力, 武田 一貴
  第28回日本野生動物医学会大会 (2022).

  • URL

  最優秀賞受賞
• "小笠原諸島の外来クマネズミに対する抗血液凝固系殺鼠剤ダイファシノンの薬物動態・薬力学(PK/PD)解析による感受性評価"
  清水 敬太, 佐藤 美侑, 片山 雅史, 中山 翔太, 池中 良徳, 一瀬貴大, 石塚 真由美, 鎌田 亮, 小山田 佑輔, 港 隆一, 橋本 琢磨, 武田 一貴
  第165回日本獣医学会学術集会 (2022).

  • URL

  優秀発表賞（野生動物分科会）受賞
• "インク由来化学物質群のゼブラフィッシュ胚への芳香族炭化水素受容体(AhR)を介する毒性影響評価"
  更田 葵依, 武田 一貴, 清水 敬太, 寺崎 正紀, 鎌田 亮
  第165回日本獣医学会学術集会 (2022).
• "Gazing at the risk of anticoagulant rodenticides (ARs) application from aquatic biota: Attempt to evaluate ARs toxicity in sea turtles"
  Yoshiya Yamamura, Chiyo Kitayama, Satomi Kondo, Kazuki Takeda, Takahiro Ichise, Yoshinori Ikenaka, Mayumi Ishizuka, Shouta M.M. Nakayama
  The 49th Annual Meeting of the Japanese Society of Toxicology (2022).

  Symposium (nominated): On the frontline of wildlife toxicity assessment by young researchers
• "Construction of a method for predicting animal species differences in chemical sensitivity from human single nucleotide polymorphisms using molecular simulation"
  Kazuki Takeda, Nobuaki Yasuo, Masakazu Sekijima
  The 49th Annual Meeting of the Japanese Society of Toxicology (2022).

  Symposium (nominated): On the frontline of wildlife toxicity assessment by young researchers
• "Characterization of Clotting Factor IX Transcript variant 2 by cultured cells assay and Alphafold2"
  Kanami Watanabe, Ryo Sato, Ryo Kamata, and Kazuki Takeda
  The 49th Annual Meeting of the Japanese Society of Toxicology (2022).
• "Evaluation of Toxicological Effects of Low Concentration Mixed Exposure of Perfluoroalkyl Substances (PFASs) on Mice"
  Kazuki Takeda, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Ryo Kamata
  Joint Conference on Environmental Chemicals (2022).
• "Evaluation of Aromatic Hydrocarbon Receptor (AhR) Agonistic Activity of Sensitizer-Related Compounds Using Zebrafish"
  更田 葵依、武田 一貴、清水 敬太、寺崎 正紀、鎌田 亮
  Joint Conference on Environmental Chemicals (2022).

  SETAC Award
• "Development of resources for assessing the effects of pollutants on green sea turtles"
  Masafumi Katayama; Tomokazu Fukuda; Manabu Onuma; Kazuki Takeda; Satomi Kondo; Shouta MM Nakayama
  Japan Geoscience Union Meeting 2022 (2022).

  • URL
• "環境汚染物質による細胞内受容体作用と生物影響の検出"
  鎌田 亮
  岩手大学ソフトパス理工学総合研究センター環境科学・工学研究グループ勉強会 (2022).
• "Functional analysis of splicing variant 2 of blood coagulation factor IX"
  Kanami Watanabe, Ryo Sato, Ryo Kamata, and Kazuki Takeda
  The 4th Spring Meeting of the Japanese Society of Comparative Pharmacology and Toxicology (2022).
• "Characterization of Clotting Factor IX Transcript variant 2"
  Kanami Watanabe, Ryo Sato, Ryo Kamata, and Kazuki Takeda
  5th International Chemical Hazard Symposium (2022).

International conference

• "ESTIMATING SUSCEPTIBILITY OF RODENTICIDE BY MOLECULAR DYNAMICS & MACHINE LEARNING USING 3D STRUCTURES OF VITAMIN K EPOXIDE REDUCTASE"
  Kazuki Takeda, Nobuaki Yasuo, Kanami Watanabe, Ryo Sato, Ryo Kamata, and Masakazu Sekijima
  The Pure and Applied Chemistry International Conference 2022 (2022).

  Invited Presentation

Awards

• "最優秀賞（口頭発表部門）：2022 年に捕獲した小笠原諸島父島の外来クマネズミにおける殺鼠剤ダイ ファシノンの薬物動態‧薬力学（PK/PD）解析による感受性評価"
  清水 敬太, 佐藤 美侑, 片山 雅史, 中山 翔太, 池中 良徳, 一瀬貴大, 石塚 真由美, 鎌田 亮, 小山田 佑輔, 港 隆一, 橋本 琢磨, 田中 和之, 谷川 力, 武田 一貴
  第28回野生動物医学会大会 (2022).

  • URL
• "優秀発表賞（野生動物分科会）：小笠原諸島の外来クマネズミに対する抗血液凝固系殺鼠剤ダイファシノンの薬物動態・薬力学(PK/PD)解析による感受性評価"
  清水 敬太, 佐藤 美侑, 片山 雅史, 中山 翔太, 池中 良徳, 一瀬貴大, 石塚 真由美, 鎌田 亮, 小山田 佑輔, 港 隆一, 橋本 琢磨, 田中 和之, 谷川 力, 武田 一貴
  第165回日本獣医学会学術集会 (2022).

  • URL
• "Evaluation of Aromatic Hydrocarbon Receptor (AhR) Agonistic Activity of Sensitizer-Related Compounds Using Zebrafish"
  Aoi Sarata, Kazuki Takeda, Keita Shimizu, Masanori Terasaki, Ryo Kamata
  Joint Conference on Environmental Chemicals (2022).

  • URL

Books

• "Chapter 2 Animal Pathology 6-Congenital Anomalies. Chapter 3 Animal Pharmacology 8-Drugs acting on blood and immune system."
  Kazuki Takeda
  Gakken (2022).

  • URL

  Essential Textbook for Pet Nurse（written in Japanese）