Publications

2024

Publication

• "Assessment of the Aryl Hydrocarbon Receptor–Mediated Effects of Aromatic Sensitizers in Paper Recycling Effluent Employing Zebrafish Embryos and in Silico Docking"
  Kazuki Takeda, Aoi Sarata, Masanori Terasaki, Akira Kubota, Keita Shimizu, Ryo Kamata
  Environmental Toxicology and Chemistry 43, 10, 2176–2188 (2024).

  • DOI: https://doi.org/10.1002/etc.5969
• "Exploring 2-methyl–substituted vitamin K3 derivatives with potent inhibitory activity against the 3CL protease of SARS-CoV-2"
  Ryohto Koharazawa, Mayu Hayakawa, Kazuki Takeda, Kotone Miyazaki, Chisato Tode, Yoshihisa Hirota, Yoshitomo Suhara
  Bioorganic & Medicinal Chemistry Letters 100, 129642 (2024).

  • DOI: https://doi.org/10.1016/j.bmcl.2024.129642
• "Sensitivity assessment of diphacinone by pharmacokinetic analysis in invasive black rats in the Bonin (Ogasawara) Archipelago, Japan"
  Kazuki Takeda, Keita Shimizu, Miyu Sato, Masafumi Katayama, Shouta M.M. Nakayama, Kotaro Tanaka, Yoshinori Ikenaka, Takuma Hashimoto, Ryuichi Minato, Yusuke Oyamada, Kazuyuki D. Tanaka, Goro Kimura, Tsutomu Tanikawa, Keisuke Kato, Taichi Kusakabe, Mayumi Ishizuka, Ryo Kamata
  Pesticide Biochemistry and Physiology 199, 105767 (2024).

  • DOI: https://doi.org/10.1016/j.pestbp.2023.105767
• "Toxicity Assessment of Mixed Exposure of Nine Perfluoroalkyl Substances at Concentrations Relevant to Daily Intake"
  Kazuki Takeda, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Makoto Sugiyama, Saeka Eto, Kio Suzuki, Ryo Kamata
  Toxics 12, 1, 52 (2024).

  • DOI: https://doi.org/10.3390/toxics12010052

  Editor’s Choice

Domestic conference

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• "Trends in Vitamins and Rodenticides Based on Structural Biology"
  Kazuki Takeda
  2nd Innovation Meeting Connecting to the Next Generation of Vitaminology (2024).

  Invited
• "Molecular Simulation in Covalent Chemical Toxicity Assessment"
  Kazuki Takeda
  2nd Symposium of Additive Chemical Science Devision of The Japanese Society of Toxicology (2024).

  Invited
• "Evaluation of Vitamin K Derivatives Directed at Inhibition of Enzymes Involved in SARS-CoV-2 Proliferation"
  Mayu Hayakawa, Daiki Homma, Ryoto Obarasawa, Kazuki Takeda, Yoshitomo Suhara, Yoshihisa Hirota]
  The 144th Annual Meeting of the Pharmaceutical Society of Japan (2024).
• "Assessment of Testicular Toxicity of Mixed Exposure of Nine Perfluoroalkyl Substances (PFASs) at Concentrations Relevant to Daily Intake"
  Wakana Yoshimura, Taki Saito, Sakura Sasaki, Makoto Sugiyama, Ryo Kamata, Kazuki Takeda
  167th Annual Meeting of the Japanese Society of Veterinary Science (2024).

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  Pharmacology and Toxicology Section Excellent Presentation Award
• "Predicting the Pharmacokinetics of Anticoagulant Rodenticides in Wildlife Using Partial Differential Equation Modeling"
  Misaki Fukamatsu, Masafumi Katayama, Shouta M.M. Nakayama, Moyu Miyamae, Ryo Kamata, Kazuki Takeda
  The 167th Annual Meeting of The Society of Japanese Veterinary Medical Sciences (2024).

  • URL

  Wildlife Science Section Excellent Presentation Award
• "In silico Binding-Proteomics Evaluation Pipeline Using AlphaFold2 Whole Structural Proteome"
  Teppei Hayama, Rin Sugawara, Ryo Kamata, Kazuki Takeda
  The 167th Annual Meeting of The Society of Japanese Veterinary Medical Sciences (2024).
• "Understanding species differences in drug susceptibility based on protein 3D structures: A case study on VKOR"
  Kazuki Takeda, Moyu Miyamae, Teppei Hayama, Sanae Yamamoto, Ryo Kamata
  The 51st Annual Meeting of Japanese Society of Toxicology (2024).
• "Toxicity Assessment Using the Structural Proteome in the Post-AlphaFold2 Era"
  Kazuki Takeda
  Digital Toxicology Conference (2024).

  Invited
• "Machine Learning Analysis of the Results of the Japanese Society of Toxicology Career Path Questionnaire"
  Kazuki Takeda
  The 51st Annual Meeting of Japanese Society of Toxicology (2024).

  Invited
• "Evaluation of the Aromatic Hydrocarbon Receptor (AhR) Activation Potential by Sensitizer-Related Compounds in Waste Paper Recycling Effluent"
  Jiayan Sun, Kazuki Takeda, Masanori Terasaki, Akifumi Eguchi, Akira Kubota, Aoi Sarata, Keita Shimizu, Ryo Kamata
  The 51st Annual Meeting of Japanese Society of Toxicology (2024).

  • URL

  Student Poster Presentation Award
• "Evaluation of species differences in animal susceptibility to warfarin rodenticides based on in silico protein structure analysis"
  Moyu Miyamae, Sanae Yamamoto, Ryo Kamata, Kazuki Takeda
  3rd Joint Conference on Environmental Chemicals (2024).

  • URL

  Wellington Laboratories Award
• "Pharmacokinetic and Pharmacodynamic (PK/PD) Analysis for Susceptibility Assessment of the Invasive Rat Population in Ogasawara Father Island to the Rodenticide Diphacinone"
  Kotaro Tanaka, Keita Shimizu, Miyu Sato, Masafumi Katayama, Shouta M.M. Nakayama, Yoshinori Ikenaka, Takahiro Ichise, Takuma Hashimoto, Ryuichi Minato, Yusuke Oyamada, Kazuyuki D. Tanaka, Goro Kimura, Tsutomu Tanikawa, Keisuke Kato, Taichi Kusakabe, Mayumi Ishizuka, Ryo Kamata, Kazuki Takeda
  3rd Joint Conference on Environmental Chemicals (2024).

  • URL

  SETAC Award
• "Drug Discovery Chemistry and Toxicology in Age of Post-AlphaFold2"
  Kazuki Takeda
  The 25th Continuing Education Course of the Japanese Society of Toxicology (2024).

  Invited
• "Search for Molecules Responsible for Differences in Drug Efficacy between cis-trans Isomers of Warfarin Rodenticides"
  Moyu Miyamae, Satoru Nagaoka, Sanae Yamamoto, Ryo Kamata, Kazuki Takeda
  6th International Chemical Hazard Symposium (2024).

International conference

• "Comparisons of dominant species of rodents and their resistance factors to anticoagulant rodenticides between Japan, the United States and Europe."
  Satoru Nagaoka, Yasushi Kiyokawa, Tsutomu Tanikawa, Kazuyuki Tanaka, Kazuki Takeda, Mayumi Ishizuka]
  XXVII International Congress of Entomology (ICE2024) (2024).

  Invited

Awards

• "Pharmacology and Toxicology Section Excellent Presentation Award: Evaluation of Testicular Toxicity Effects Due to Mixed Exposure of Nine Types of Perfluoroalkyl Substances (PFASs) at Everyday Intake Levels"
  Wakana Yoshimura
  167th Annual Meeting of the Japanese Society of Veterinary Science (2024).

  • URL
• "Wildlife Science Section Excellent Presentation Award: Prediction of the Pharmacokinetics of Anticoagulant Rodenticides in Wildlife Using Partial Differential Equation Modeling"
  Misaki Fukamatsu
  167th Annual Meeting of the Japanese Society of Veterinary Science (2024).

  • URL
• "SETAC Award: Pharmacokinetic and Pharmacodynamic (PK/PD) Analysis for Susceptibility Assessment of the Invasive Rat Population in Ogasawara Father Island to the Rodenticide Diphacinone"
  Kotaro Tanaka
  3rd Joint Conference on Environmental Chemicals (2024).

  • URL
• "Wellington Laboratories Award: Evaluation of Species-Specific Susceptibility to Warfarin-like Rodenticides Based on In Silico Protein Structure Analysis"
  Moyu Miyamae
  3rd Annual Meeting of the Joint Conference on Environmental Chemicals (2024).

  • URL
• "Student Poster Presentation Award: Evaluation of Aromatic Hydrocarbon Receptor (AhR) Activation by Sensitizer-Related Substances in Recycled Paper Mill Effluent"
  Jiayan SUN
  51st Annual Meeting of the Japanese Society of Toxicology (2024).

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Japanese Proceedings

• "ゲノム情報を用いた構造生物学：ポストAlphaFold2 の環境毒性学"
  武田 一貴
  地球環境 29, 2, 173-181 (2024).

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• "構造生物学に基づくビタミンと殺鼠剤の新展開"
  武田 一貴
  ビタミン 98, 9, 445 (2024).

  • URL
• "AI（深層学習）を用いた毒性予測手法"
  日本毒性学会 毒性学トピックス解説 (2024).

  • URL
• "獣医×毒性×シミュレーション×AIで挑む環境汚染問題"
  武田 一貴
  公益財団法人八戸地域振興センター情報誌「てくのろじぃ・Akros」 125 (2024).

  • URL
• "深層学習によるタンパク質構造予測が拓く環境毒性学研究"
  武田 一貴
  日本内分泌攪乱学会ニュースレター 27, 1, 5 (2024).

  • URL