Publications

2025

Publication

• "Development and Mechanistic Evaluation of a Lithocholic Acid Derivative as an Environmentally Safe Rodenticide"
  Kazuki Takeda*, Kana Okamura, Satoru Nagaoka, Chiharu Ogura, Misaki Fukamatsu, Mayumi Degawa, Hiroyuki Kagechika, Kenji Ohgane, Ryo Kamata, Aya Tanatani*
  ACS Pharmacology & Translational Science (2025).

  • DOI: https://doi.org/10.1021/acsptsci.5c00059
• "A New Class of Vitamin K Analogues Containing the Side Chain of Retinoic Acid Have Enhanced Activity for Inducing Neuronal Differentiation"
  Yoshihisa Hirota, Taiki Sato, Rina Watanabe, Kazuki Takeda, Sho Sano, Satoshi Asano, Yuki Shibahashi, Yumi Yasuda, Yuta Takagi, Yutaro Yamashita, Wu YuXin, Mikino Arakawa, Yuri Maitani, Vannessa Lawai, Kurumi Nakagawa, Natsuko Furukawa, Atsuko Takeuchi, Chisato Tode, Maya Kamao, Akimori Wada, Zainab Ngaini, Yoshitomo Suhara
  ACS Chemical Neuroscience 16, 15, 2812–2828 (2025).

  • DOI: https://doi.org/10.1021/acschemneuro.5c00111
• "Comprehensive molecular docking on the AlphaFold-predicted protein structure proteome: identifying target protein candidates for puberulic acid"
  Teppei Hayama, Rin Sugawara, Ryo Kamata, Masakazu Sekijima, Kazuki Takeda*
  The Journal of Toxicological Sciences 50, 7, 309-324 (2025).

  • DOI: https://doi.org/10.2131/jts.50.309
• "Protective function of the voltage-gated potassium channel Kv11.3 in a mouse model of cardiac ischemia/reperfusion injury"
  Hayato Sasaki, Kazuki Otake, Kazuki Takeda, Karin Tesaki, Eiki Takahashi, Jumpei Yasuda, Shizukaze Matsuda, Ayumu Kawasaki, Masaki Watanabe, Kosuke Otani, Muneyoshi Okada, Masakazu Sekijima, Hideyuki Yamawaki, Nobuya Sasaki
  PLOS One (2025).

  • URL
  • DOI: https://doi.org/10.1371/journal.pone.0323428
• "Comprehensive Molecular Docking on the AlphaFold-Predicted Protein Structure Proteome: Identifying Target Protein Candidates for Puberulic Acid, a Suspected Lethal Nephrotoxin"
  Teppei Hayama, Rin Sugawara, Ryo Kamata, Masakazu Sekijima, Kazuki Takeda
  bioRxiv (2025).

  • DOI: https://doi.org/10.1101/2025.01.30.635827

Domestic conference

• "Rodenticide Use in Japan – Super Rats in Tokyo and Susceptibility of Invasive Black Rats to Rodenticides on Chichijima, Ogasawara Islands"
  Kazuki Takeda
  The Mammal Society of Japan Annual Meeting 2025 (2025).
• "Development of in silico target protein prediction pipeline by comprehensive molecular docking on the complete AlphaFold Proteome"
  Teppei Hayama, Rin Sugawara, Ryo Kamata, Masakazu Sekijima, Kazuki Takeda
  2nd Meeting of Researchers of Kitasato Institute (DocTALK) (2025).
• "Prediction of Anticoagulant Rodenticide Resistance through VKORC1 Variant Analysis Using Molecular Dynamics and Machine Learning"
  Moyu Miyamae, Ryo Kamata, Kazuki Takeda
  2nd Meeting of Researchers of Kitasato Institute (DocTALK) (2025).
• "分子動力学と機械学習を用いたVKORC1変異型解析による抗血液凝固系殺鼠剤抵抗性の予測"
  宮前 萌優, 鎌田 亮, 武田 一貴
  (2025).

  若手奨励賞
• "Testicular Toxicity Assessment of a Nine-Component PFAS Mixture at Human-Relevant Daily Exposure Levels in Mice"
  Wakana Yoshimura,Hiromi Kusaka, Chihiro Kanno, Makoto Sugiyama, Masashi Nagano, Ryo Kamata, Kazuki Takeda
  The 38th Kitasato University Bioscience Forum (2025).

  若手奨励賞
• "Development of an In Silico Target Protein Prediction Method via Comprehensive Molecular Docking to AlphaFold-Predicted Proteome Structures: A Case Study on Puberulic Acid"
  Teppei Hayama, Rin Sugawara, Ryo Kamata, Masakazu Sekijima, Kazuki Takeda
  4th Joint Conference on Environmental Chemicals (2025).

  American Chemical Society Award
• "Development of an Odor Prediction Model Using Molecular Docking Simulations and Machine Learning"
  Koki Takaguchi, Keita Yamauchi, Akifumi Eguchi, Kazuki Takeda
  4th Joint Conference on Environmental Chemicals (2025).
• "Evaluation of Testicular Toxicity in Mice Induced by Mixed Exposure to Nine Linear Perfluoroalkyl Compounds at Levels Equivalent to Daily Human Intake"
  Wakana Yoshimura,Hiromi Kusaka, Chihiro Kanno, Makoto Sugiyama, Masashi Nagano, Ryo Kamata, Kazuki Takeda
  4th Joint Conference on Environmental Chemicals (2025).

  Young Investigator Award, Japanese Society of Environmental Toxicology
• "Rodenticidal Effect and Mechanistic Elucidation of Dcha-20, a Lithocholic Acid Derivative with a Novel Mode of Action"
  Misaki Fukamatsu, Chiharu Ogura, Satoru Nagaoka, Kana Okamura, Miyuna Yoshiwara, Hiroyuki Kagechika, Ryo Kamata, Aya Tanatani, Kazuki Takeda
  4th Joint Conference on Environmental Chemicals (2025).

  Wellignton Laboratories Award
• "Accuracy Assessment of Binding Proteomics: A Comprehensive Molecular Docking-Based Target Identification Method"
  Rin Sugawara, Teppei Hayama, Ryo Kamata, Kazuki Takeda
  52nd Annual Meeting of the Japanese Society of Toxicology (2025).
• "Rodenticidal Effect and Toxicity Mechanism of Dcha-20, a Novel Vitamin D Receptor Agonist with a Lithocholic Acid Scaffold"
  Misaki Fukamatsu, Chiharu Ogura, Satoru Nagaoka, Kana Okamura, Miyuna Yoshiwara, Hiroyuki Kagechika, Ryo Kamata, Aya Tanatani, Kazuki Takeda
  52nd Annual Meeting of the Japanese Society of Toxicology (2025).

  学生ポスター発表賞受賞
• "Identification of Potential Toxicity Targets of Puberulic Acid via Comprehensive Molecular Docking “Binding Proteomics” Analysis on the Protein Structure Proteome"
  Kazuki Takeda, Teppei Hayama, Rin Sugawara, Masakazu Sekijima, Ryo Kamata
  52nd Annual Meeting of the Japanese Society of Toxicology (2025).
• "Summary of Career Path Survey at the 51st JSOT Annual Meeting Based on Machine Learning Analysis"
  Kazuki Takeda
  52nd Annual Meeting of the Japanese Society of Toxicology (2025).

  Invited
• "Toxicology × Emerging Technologies: Rethinking the Future of Toxicology – Introduction"
  Kazuki Takeda
  52nd Annual Meeting of the Japanese Society of Toxicology (2025).

  Invited
• "Evaluation of Testicular Toxicity in Male Mice Induced by Mixed Exposure to Nine Perfluoroalkyl Substances (PFASs) at Levels Equivalent to Daily Intake"
  Wakana Yoshimura,Hiromi Kusaka, Chihiro Kanno, Makoto Sugiyama, Masashi Nagano, Ryo Kamata, Kazuki Takeda
  52nd Annual Meeting of the Japanese Society of Toxicology (2025).
• "Application of the Non-Secosteroidal Vitamin D Derivative Dcha-20 as a Rodenticide"
  Miyuna Yoshiwara, Chiharu Ogura, Satoru Nagaoka, Misaki Fukamatsu, Kana Okamura, Hiroyuki Kagechika, Ryo Kamata, Aya Tanatani, Kazuki Takeda
  77th Annual Meeting of The Vitamin Society of Japan (2025).

  • URL
• "Development of Derivatives of Vitamin K3 with Enhanced 3CL Protease Inhibitory Activity"
  Miki Sasajima, Mika Okamoto, Ryohto Oharazawa, Mayu Hayamawa, Kazuki Takeda, Hirohisa Hirota, Masanori Baba, Yoshitomo Suhara
  77th Annual Meeting of The Vitamin Society of Japan (2025).

  • URL
• "Unraveling Drug Sensitivity, Species Differences, and Individual Variability of Vitamin K Cycle-Related Proteins through Structural Science"
  Kazuki Takeda
  77th Annual Meeting of The Vitamin Society of Japan (2025).

  • URL

  Special Lecture by Young Investigators
• "Rodenticidal Activity of the Lithocholic Acid Derivative Dcha-20"
  Aya Tanatani, Kana Okamura, Chiharu Ogura, Kazuki Takeda, Satoru Nagaoka, Hiroyuki Kagechika
  77th Annual Meeting of The Vitamin Society of Japan (2025).

  • URL
• "Structural characterization of the human olfactory receptor superfamily"
  Keita Yamauchi, Koki Takaguchi, Teppei Hayama, Rin Sugawara, Ryo Kamata, Akifumi Eguchi, Kazuki Takeda
  7th Spring Meeting of the Japanese Society of Veterinary Pharmacology and Toxicology (2025).
• "A Novel Species-Sensitive Animal Species Difference Assessment Method for Anti-Haemagglutinating Rodenticides by Machine Learning of Target Molecular Structure Modeling"
  Moyu Miyamae;Sanae Yamamoto;Ryo Kamata;Kazuki Takeda
  7th Spring Meeting of the Japanese Society of Veterinary Pharmacology and Toxicology (2025).
• "''Structural Tokicology" from Towada Campus, Aomori, Japan"
  Kazuki Takeda
  1st Meeting of Researchers of Kitasato Institute (2025).

  • URL
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  null (2025).

  • URL

  優秀発表賞受賞
• "null"
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  Kazuki Takeda
  null (2025).

  指名シンポジウム

International conference

• "Evaluation of species differences in susceptibility to anticoagulant rodenticides based on in silico protein structure analysis"
  Moyu Miyamae, Sanae Yamamoto, Ryo Kamata, Kazuki Takeda
  The Pure and Applied Chemistry International Conference (PACCON) 2025 (2025).

  Invited

Awards

• "Young Scientist Award, Testicular Toxicity Assessment of a Nine-Component PFAS Mixture at Human-Relevant Daily Exposure Levels in Mice"
  Wakana Yoshimura
  38th Kitasato University Bioscience Forum (2025) (2025).
• "Young Scientist Award, Prediction of Anticoagulant Rodenticide Resistance through VKORC1 Variant Analysis Using Molecular Dynamics and Machine Learning"
  宮前 萌優
  38th Kitasato University Bioscience Forum (2025) (2025).
• "Young Investigator Award, Japanese Society of Environmental Toxicology: Evaluation of Testicular Toxicity in Mice Induced by Mixed Exposure to Nine Linear Perfluoroalkyl Compounds at Levels Equivalent to Daily Human Intake"
  Wakana Yoshimura
  4th Joint Conference on Environmental Chemicals (2025).
• "American Chemical Society Award: Development of an In Silico Target Protein Prediction Method via Comprehensive Molecular Docking to AlphaFold-Predicted Proteome Structures: A Case Study on Puberulic Acid"
  Teppei Hayama
  4th Joint Conference on Environmental Chemicals (2025).
• "Wellignton Laboratories Award: Rodenticidal Effect and Mechanistic Elucidation of Dcha-20, a Lithocholic Acid Derivative with a Novel Mode of Action"
  Misaki Fukamatsu
  4th Joint Conference on Environmental Chemicals (2025).
• "Student Poster Presentation Award: Mechanistic Analysis of Dcha-20, a Novel Rodenticide with a Lithocholic Acid Scaffold"
  Misaki Fukamatsu
  52nd Annual Meeting of the Japanese Society of Toxicology (2025).
• "Best Article 2024 "Assessment of the Aryl Hydrocarbon Receptor–Mediated Effects of Aromatic Sensitizers in Paper Recycling Effluent Employing Zebrafish Embryos and in Silico Docking""
  Kazuki Takeda and Ryo Kamata
  School of Veterinary Medicine, Kitasato University (2025).

  • URL
  • DOI: https://doi.org/10.1002/etc.5969
• "Excellent Presentation Award: Development of an In Silico Evaluation Method for Chemical Binding Proteins Through Comprehensive Molecular Docking Simulation"
  Rin Sugawara
  7th Pharmaceutical Toxicity Mechanisms Conference (2025).

  • URL